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Published on: January 20, 2023
Hederacolchiside C inhibits Enterovirus 71 propagation through activating innate immunity
Yan-Er Wang1, Nai-Xin Kang2, Jian-Ping Zhao3
1College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Abstract:
Enterovirus 71 (EV71), a newly emerging life-threatening pathogen induces hand-foot-mouth disease (HFMD), no effective vaccines or specific anti-viral treatments are currently available. In this study, the activity of hederacolchiside C (HSC) against EV71 was investigated, and the antiviral mechanism was explored. HSC displayed apparent antiviral activity in EV71-infected cells probably through activating the host innate immunity. Comparing with EV71-infected group at 24 hpi, the group pretreated with HSC dramatically increased the expression of MAVS, p-IRF3, IRF3 and IFN-β, the innate immune effectors related to innate immunity. In addition, HSC displayed stronger antiviral activity in EV71-infected suckling mice in comparison with Ribavirin, a broad-spectrum antiviral drug. The results suggest that HSC could have potential as a pharmaceutical drug for HFMD.
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