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Updated: Jan 21, 2026

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1
Published on: April 8, 2009
Serologic evidence of widespread Toscana virus infection in Bulgaria
Iva Christova1, Elitsa Panayotova1, Iva Trifonova1
1National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Background:
Toscana virus (TOSV) is an emerging sandfly-borne virus that is endemic in Mediterranean countries.
Methods:
In order to detect TOSV circulation among the human population of Bulgaria, serum samples from 459 apparently healthy adult individuals, residing in19 out of 28 districts in the country, were tested for the presence of IgG antibodies to TOSV.
Results:
An overall seroprevalence rate of 24.4% was observed, ranging from 4.4% to 53.5% in the districts. Rates were highest in persons over 60 years of age and residing in the southern districts.
Conclusion:
The results of the first TOSV seroprevalence study in Bulgaria revealed that infection is widespread. Physicians should be aware of the virus circulation during summer and consider the diagnosis in cases of febrile illness, meningitis or meningoencephalitis.
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