Related Experiment Video
Updated: Jan 21, 2026
10:03
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
737
Hypertension: An immune related disorder?
Eleni Sereti1, Kimon S Stamatelopoulos2, Nikolaos A Zakopoulos2
1Department of Immunology, Alexandra Hospital, Athens University School of Medicine, Greece.
Clinical Immunology (Orlando, Fla.)
|August 12, 2019
Summary
Hypertension may involve immune system changes. This study found higher immunoglobulin levels and lower T-cell counts (CD3+, CD4+, CD8+) in hypertensive patients, suggesting immune dysregulation contributes to high blood pressure.
Area of Science:
- Immunology
- Cardiovascular Disease
- Hypertension Research
Background:
- Hypertension is a complex condition with multifactorial etiology.
- Immune dysregulation is a proposed contributing factor to hypertension.
- Subclinical atherosclerosis is a common complication of hypertension.
Purpose of the Study:
- To investigate immune system alterations in hypertensive patients.
- To compare immunological profiles of hypertensive patients and healthy controls.
- To explore the potential role of immune dysregulation in hypertension pathogenesis.
Main Methods:
- Recruited 61 hypertensive patients and 55 healthy controls.
- Assessed subclinical atherosclerosis in all participants.
- Quantified immunoglobulin levels (IgG, IgM, IgA) and complement factor C3.
- Measured peripheral blood lymphocyte subpopulations (CD3+, CD4+, CD8+).
Main Results:
- Hypertensive patients showed significantly increased IgG, IgA, and IgM levels compared to controls.
- Complement factor C3 levels were also elevated in hypertensive individuals.
- A statistically significant decrease in CD3+, CD4+, and CD8+ T-cells was observed in hypertensive patients.
Conclusions:
- Findings suggest altered cellular and humoral immune responses in hypertension pathogenesis.
- Immune dysregulation may play a role in the development of high blood pressure.
- Immunomodulatory strategies could be a future therapeutic avenue for hypertension management.
Related Concept Videos
01:38What is the Immune System?
127.0K
Overview
127.0K
02:18Intrinsically Disordered Proteins
19.2K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.2K
01:28Hypertension I: Introduction
754
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
754
01:29Hypertension II: Pathophysiology
824
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
824
01:23Hypertension V: Nursing Management
373
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
373
01:36Humoral Immune Responses
83.4K
Overview
83.4K