Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pancreatic beta-cell function in CAPD.

W G Smith1, I Hanning, D G Johnston

  • 1Department of Nephrology, Royal Hallamshire Hospital, Sheffield, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pasture flock chicken cecal microbiome responses to prebiotics and plum fiber feed amendments.

Poultry science·2017
Same author

Salmonella enterica: survival, colonization, and virulence differences among serovars.

TheScientificWorldJournal·2015
Same author

Zoonotic bacterial pathogens and mixed crop-livestock farming.

Poultry science·2015
Same author

Detection of quinolones in commercial eggs obtained from farms in the Espaíllat Province in the Dominican Republic.

Journal of food protection·2015
Same author

Hypertriglyceridaemic waist phenotype as a simple predictive marker of incident diabetes in Asian-Indian men with prediabetes.

Diabetic medicine : a journal of the British Diabetic Association·2014
Same author

A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid.

Diabetologia·2013
Same journal

Effect of Semaglutide on Measured vs Estimated Glomerular Filtration Rate.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Beyond Diffusion and Convection: Is Adsorption the Third Dimension of Dialysis?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Pivotal Clinical Trials in C3 Glomerulopathy: answers and remaining uncertainties.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Urinary protein vs albumin for assessing kidney failure risk in chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Systolic blood pressure and albuminuria reduction mediate cardiovascular benefits of finerenone in T2 diabetes and CKD.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Bortezomib-Cyclophosphamide-Dexamethasone versus Rituximab in PGNMID.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
See all related articles

Uremic patients show increased pancreatic beta-cell peptide levels and exaggerated responses to glucagon stimulation. Continuous ambulatory peritoneal dialysis (CAPD) does not adversely affect beta-cell function in these patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Metabolic Research

Background:

  • Uremia, a condition of chronic kidney disease, can affect endocrine function.
  • Pancreatic beta-cell function is crucial for glucose homeostasis.
  • The impact of renal replacement therapies on beta-cell function requires investigation.

Purpose of the Study:

  • To evaluate pancreatic beta-cell function in patients with uremia.
  • To compare beta-cell function in non-dialyzed, hemodialysis, and continuous ambulatory peritoneal dialysis (CAPD) patients.
  • To determine if CAPD specifically impacts beta-cell integrity.

Main Methods:

  • Assessed beta-cell peptides (insulin, c-peptide) in peripheral blood.
  • Administered intravenous glucagon (1 mg) stimulation.

Related Experiment Videos

  • Compared 30 uraemic patients (10 each: chronic renal failure, hemodialysis, CAPD) with 8 healthy controls.

    • Main Results:

    • Uremic patients exhibited significantly higher fasting and glucagon-stimulated c-peptide levels compared to controls.
    • An exaggerated and delayed blood glucose response to glucagon was observed in uremic subjects.
    • Insulin response to glucagon was normal, but return to basal levels was delayed in uremia.
    • CAPD patients showed similar beta-cell responses to hemodialysis and non-dialyzed uraemic patients.

    Conclusions:

    • Uremia itself, not CAPD treatment, causes abnormalities in pancreatic beta-cell function.
    • CAPD does not appear to be detrimental to beta-cell integrity.
    • Findings suggest uremia impacts glucose metabolism and beta-cell peptide secretion independently of CAPD.