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Updated: Jan 21, 2026
07:20
Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
Published on: August 8, 2014
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Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma
Stefan Porubsky1, Peter Jessup2, Damien Kee3,4
1Institute of Pathology, University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Stefan.porubsky@umm.de.
Virchows Archiv : an International Journal of Pathology
|August 12, 2019
Summary
This study identified sebaceous differentiation in thymic carcinoma, revealing fibroblast growth factor receptor 2 (FGFR2) amplification. This finding may guide the search for actionable genomic alterations in mediastinal tumors.
Area of Science:
- Oncology
- Pathology
- Genomics
Background:
- Investigating sebaceous differentiation in thymus tumors to identify actionable genomic alterations.
- Screening normal, hyperplastic thymuses, thymomas, and thymic carcinomas for sebaceous differentiation markers.
Observation:
- One primary thymic carcinoma exhibited sebaceous carcinoma morphology with adipophilin and androgen receptor (AR) expression.
- Next-generation sequencing (NGS) identified high-level fibroblast growth factor receptor 2 (FGFR2) amplification in this case.
Findings:
- No sebaceous morphology was observed in normal thymuses or thymomas.
- Adipophilin positivity without AR co-expression occurred occasionally in thymic epithelial cells and macrophages.
Implications:
- Thymic sebaceous carcinoma diagnosis should be considered for thymic carcinomas with foamy or clear cell features.
- Testing for FGFR2 amplification is recommended for identifying actionable genomic alterations in mediastinal sebaceous carcinomas.
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