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Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
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Experimental Autoimmune Prostatitis Induces Learning-Memory Impairment and Structural Neuroplastic Changes in Mice.

Hexi Du1,2,3, Xianguo Chen1,2,3, Li Zhang1,2,3

  • 1Department of Urology, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, No. 218 Jixi Road, Hefei, 230022, People's Republic of China.

Cellular and Molecular Neurobiology
|August 12, 2019
PubMed
Summary

Experimental autoimmune prostatitis (EAP) in mice impairs learning and memory. This cognitive decline is linked to reduced dendritic complexity, synaptic changes, and increased microglial activation in the hippocampus.

Keywords:
Cognitive impairmentEAPMicroglia-synapse contactsMicroglial activationSynaptic ultrastructure

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Area of Science:

  • Neuroscience
  • Immunology
  • Urology

Background:

  • Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is associated with cognitive deficits.
  • The pathogenesis of CP/CPPS-related cognitive decline is not well understood.

Purpose of the Study:

  • To investigate the impact of experimental autoimmune prostatitis (EAP) on cognitive function in a mouse model.
  • To explore the underlying neurobiological mechanisms, including neuroplasticity and neuroinflammation.

Main Methods:

  • Induction of EAP in Non-obese diabetic mice using prostate antigen and adjuvant.
  • Assessment of cognitive performance using Morris water maze and novel object recognition tests.
  • Evaluation of dendritic complexity, spine density, synaptic morphology, and microglial activation via Golgi-Cox staining, transmission electron microscopy, and immunofluorescence.

Main Results:

  • EAP induction led to significant deficits in learning and memory.
  • Reduced dendritic complexity and spine density were observed in EAP mice.
  • Synaptic proteins (synaptophysin, PSD95) decreased, indicating impaired synaptic plasticity.
  • EAP mice exhibited hippocampal microglial activation and increased microglia-synapse contacts.

Conclusions:

  • Experimental autoimmune prostatitis causes cognitive impairment in mice.
  • Neuroplastic changes and hippocampal microglial activation are associated with EAP-induced cognitive decline.
  • These findings suggest a link between prostatitis, neuroinflammation, and cognitive dysfunction.