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Dacomitinib in non-small-cell lung cancer: a comprehensive review for clinical application

Hao Sun1, Yi-Long Wu2

  • 1Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, First Affiliated Hospital of South China University of Technology, Guangzhou 510080, PR China.

Future Oncology (London, England)
|August 13, 2019
PubMed

Insights

Dacomitinib improves progression-free survival in advanced non-small-cell lung cancer with EGFR mutations. Dose reductions manage side effects without compromising efficacy, supporting its role as a first-line treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Dacomitinib is a second-generation EGFR tyrosine kinase inhibitor (TKI). It irreversibly inhibits EGFR/Her1, Her2, and Her4 subtypes.
  • Its efficacy is comparable to other TKIs in treating non-small-cell lung cancer (NSCLC).

Purpose of the Study:

  • To evaluate dacomitinib as a first-line treatment for advanced NSCLC with EGFR mutations.
  • To assess the impact of dose reductions on dacomitinib's efficacy and adverse events.

Main Methods:

  • The ARCHER 1050 trial compared dacomitinib with gefitinib in advanced NSCLC patients.
  • Adverse events and the effect of dose reductions on efficacy were analyzed.

Main Results:

  • Dacomitinib demonstrated improved progression-free survival compared to gefitinib.
  • Dose reductions effectively decreased the incidence and severity of adverse events without reducing efficacy.

Conclusions:

  • Dacomitinib is a viable first-line treatment option for advanced NSCLC with EGFR mutations.
  • Dose adjustments can mitigate toxicity, enhancing patient tolerability.
  • Future comparisons with osimertinib are needed to optimize TKI treatment strategies.
Keywords:
TKIdacomitinibfirst-line treatmentreview

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