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Key Articles and Guidelines in the Management of Dyslipidemia: 2019 Update
Barbara S Wiggins1, Dave Dixon2, Jessica Bellone3
1Medical University of South Carolina, Charleston, SC, USA.
Insights
Managing dyslipidemia, a key risk factor for cardiovascular disease, requires updated strategies. This resource reviews current guidelines and trials for effective lipid-lowering therapy to reduce cardiovascular events.
Area of Science:
- Cardiology
- Metabolic Disorders
- Pharmacotherapy
Background:
- Cardiovascular disease remains a leading cause of death in the US, with dyslipidemia as a major modifiable risk factor.
- Lowering low-density lipoprotein cholesterol is proven to reduce cardiovascular events.
- The field of dyslipidemia management has evolved significantly since 2006, with new therapies emerging and some older ones falling out of favor.
Purpose of the Study:
- To provide clinicians with an updated resource on dyslipidemia management.
- To compile key articles, guidelines, and practice-changing randomized controlled trials.
- To aid in reevaluating treatment strategies for optimal patient outcomes.
Main Methods:
- Literature review and synthesis of key publications in dyslipidemia.
- Inclusion of updated clinical guidelines.
- Focus on practice-changing randomized controlled trials.
Main Results:
- New lipid-lowering therapies have become available.
- Some previously used therapies have demonstrated a lack of benefit.
- Evidence continues to expand, necessitating ongoing reevaluation of treatment approaches.
Conclusions:
- Clinicians must adapt to the evolving evidence in dyslipidemia management.
- Optimal use of lipid-lowering therapies is crucial for reducing cardiovascular morbidity and mortality.
- This compilation serves as a valuable reference for current best practices.
Abstract:
Although the mortality from cardiovascular disease has declined, it remains the leading cause of morbidity and mortality in the United States. Dyslipidemia is a modifiable risk factor that plays a significant role in the development of atherosclerotic cardiovascular disease. Treating dyslipidemia by lowering cholesterol, predominately low-density lipoprotein cholesterol, has been shown to reduce cardiovascular events. The first article that provided dyslipidemia bibliographies was published in 2006. Since this time, new therapies have become available and older therapies that were once thought to provide benefit have since been shown to lack positive outcomes and have therefore fallen out of favor for routine use. As the body of evidence continues to expand, clinicians are faced with reevaluating their treatment strategies to ensure optimal outcomes and appropriate use of lipid-lowering therapies. Therefore, this compilation was created to serve as a resource for clinicians. This publication provides an update of key articles in dyslipidemia management including various guidelines and practice-changing randomized controlled trials.
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