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Acute Flaccid Myelitis: Characteristics and Outcomes of 2014 and 2016 Cases at a Single Center

Susan Matesanz1, Jennifer L McGuire2, Sarah Hopkins2

  • 1Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

The Journal of Pediatrics
|August 13, 2019
PubMed

Insights

Acute flaccid myelitis (AFM) causes spinal cord issues and limb weakness. Early viral testing in children can improve diagnosis and detection rates for this rare neurological condition.

Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Diseases

Background:

  • Acute flaccid myelitis (AFM) is a rare neurological condition.
  • AFM is characterized by spinal cord gray matter abnormalities.
  • It frequently leads to persistent motor deficits in the limbs.

Purpose of the Study:

  • To present clinical experience with AFM diagnosis, management, and outcomes in children.
  • To highlight features prompting early AFM consideration.
  • To assess the utility of early viral testing.

Main Methods:

  • Retrospective review of pediatric AFM cases from 2014 and 2016.
  • Analysis of diagnostic features and management strategies.
  • Evaluation of viral testing protocols and detection rates.

Main Results:

  • Detailed case series of children diagnosed with AFM.
  • Identification of key clinical indicators for early suspicion.
  • Findings suggest early viral testing enhances pathogen detection.

Conclusions:

  • Early recognition of specific features is crucial for timely AFM diagnosis.
  • Prompt viral testing is recommended for identifying associated infectious agents.
  • Understanding management and outcomes informs clinical practice for pediatric AFM.
Keywords:
acute flaccid myelitisenterovirusmyelitispediatricweakness

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