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Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
Published on: December 8, 2011
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Abnormal vaginal microbiome associated with vaginal mesh complications
Nikolaus Veit-Rubin1, Renaud De Tayrac2, Rufus Cartwright3
1Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Neurourology and Urodynamics
|August 13, 2019
Summary
This study found that the vaginal microbiome may change after transvaginal mesh surgery. Veillonella bacteria were more common after mesh contraction, suggesting a link to this complication.
Area of Science:
- Microbiology
- Gynecology
- Surgical Complications
Background:
- Transvaginal mesh (TVM) surgery is used for pelvic organ prolapse.
- Mesh-associated complications can occur after TVM surgery.
- The role of the vaginal microbiome in these complications is not fully understood.
Purpose of the Study:
- To investigate differences in the vaginal microbiome of women following TVM surgery.
- To compare the vaginal microbiomes of women with and without mesh-associated complications.
Main Methods:
- Vaginal DNA was isolated from patients with and without mesh complications.
- The V1-2 region of the 16S ribosomal RNA gene was amplified and sequenced.
- Microbiome richness (Chao1) and diversity (Shannon) were analyzed.
Main Results:
- No significant differences in overall richness were detected between groups.
- A trend towards higher microbial diversity was observed in women with mesh complications.
- Veillonella spp. were found to be more abundant in patients experiencing mesh contraction.
Conclusions:
- Veillonella spp. may be associated with mesh contraction after TVM surgery.
- Vaginal microbiotic dysbiosis was not identified as a factor for mesh exposure.
- Larger studies are needed to understand predispositions to mesh complications.
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