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Plasma galectin-3 levels do not differ in systemic lupus erythematosus patients
Chan-Na Zhao1,2, Yan-Mei Mao1,2, Li-Na Liu1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
International Journal of Rheumatic Diseases
|August 13, 2019
Summary
Plasma galectin-3 levels did not differ between systemic lupus erythematosus (SLE) patients and healthy individuals. Further research is needed to understand galectin-3
Area of Science:
- Immunology
- Rheumatology
- Biochemistry
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Galectin-3 is a protein with diverse biological functions.
- Its role in SLE pathogenesis requires further investigation.
Purpose of the Study:
- To determine plasma galectin-3 levels in SLE patients.
- To explore the association between galectin-3 and clinical/laboratory features of SLE.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma galectin-3.
- 180 subjects were included: 90 SLE patients and 90 healthy controls.
- Clinical and laboratory data were collected for correlation analysis.
Main Results:
- No significant difference in plasma galectin-3 levels was observed between SLE patients and controls.
- Galectin-3 levels did not correlate with SLE nephritis or disease activity.
- An inverse correlation was found between galectin-3 and immunoglobulin M (IgM).
Conclusions:
- Plasma galectin-3 levels are not significantly different in SLE patients compared to controls.
- The current study did not establish a clear role for galectin-3 in SLE.
- Additional research is warranted to fully elucidate galectin-3's function in SLE.
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