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Fabrication Techniques for Vascular and Vascularized Tissue Engineering.

Ziyu Wang1,2, Suzanne M Mithieux1,2, Anthony S Weiss1,2,3,4

  • 1School of Life and Environmental Sciences, University of Sydney, NSW, 2006, Australia.

Advanced Healthcare Materials
|August 13, 2019
PubMed
Summary

Vascular tissue engineering offers solutions for damaged blood vessels by creating synthetic grafts and prevascularized tissues. Research explores engineering and cell-based methods to fabricate functional, hierarchical vascular structures for improved patient outcomes.

Keywords:
hierarchical vasculaturesmicrovasculaturesprevascularizationtissue-engineered vascular graftsvascular tissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Vascular damage impacts all vessel types, from large arteries to microvasculatures.
  • Small-diameter vascular grafts are crucial for treating occlusive arterial diseases.
  • Engineered tissues and organs require prevascularization for survival and function.

Purpose of the Study:

  • To explore techniques for fabricating small-diameter vascular grafts.
  • To investigate methods for creating meso- and microvasculatures for tissue engineering.
  • To review engineering- and cell-based approaches for synthetic vasculature construction.

Main Methods:

  • Review of engineering-based fabrication techniques for vascular grafts.
  • Exploration of cell-based approaches for vascular tissue engineering.
  • Analysis of methods for creating hierarchical vascular structures.

Main Results:

  • Vascular tissue engineering shows promise for fabricating functional vascular grafts.
  • Techniques are being developed for both large-diameter grafts and complex meso-/microvasculatures.
  • The goal is to achieve biocompatible, mechanically robust, and rapidly integrating vascular constructs.

Conclusions:

  • Fabrication of vascular grafts and prevascularized tissues is advancing through tissue engineering.
  • Successful constructs require biocompatibility, mechanical integrity, and host integration.
  • Developing hierarchical vascular structures is key for complex tissue regeneration.