Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Humoral Immune Responses01:36

Humoral Immune Responses

83.4K
Overview
83.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.6K
Overview
83.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.5K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.8K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.8K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.7K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

6.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Modern therapy of pulmonary embolism with PERT and EKOS: an advantage also for in-hospital time?]

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same author

Molecular Tumor Board-Guided Osimertinib Therapy in EGFR L858R/Q701L-Mutant Lung Adenocarcinoma Supported by Functional Validation.

The oncologist·2026
Same author

Outcomes and prognostic factors in patients with systemic mastocytosis and an associated myeloid neoplasm: an international ECNM registry study.

Journal of hematology & oncology·2026
Same author

Prevent or Treat? Evaluating a Delayed Treatment With Nintedanib After Murine Orthotopic Tracheal Transplantation.

Transplantation direct·2026
Same author

Robotic Centrifugal Microfluidics with In-Rotation Liquid Supply for the Extraction of Multiple Liquid Biopsy Analytes in One Platform.

Biosensors·2026
Same author

Early versus delayed EKOS thrombolysis in intermediate-high risk pulmonary embolism: a retrospective multicentre analysis.

Open heart·2026

Related Experiment Video

Updated: Jan 21, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K

Platelets and Immune Responses During Thromboinflammation.

Matthias Mezger1, Henry Nording1,2, Reinhard Sauter1

  • 1University Hospital, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany.

Frontiers in Immunology
|August 13, 2019
PubMed
Summary

Platelets, beyond hemostasis, significantly influence inflammation and thrombosis. This review details their roles in coagulation, immune reactions, and tissue repair, highlighting therapeutic potential in platelet-related diseases.

Keywords:
EAEcomplementinfectioninflammationinnate immunityplateletsstroketissue remodeling

More Related Videos

Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

15.9K
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

12.4K

Related Experiment Videos

Last Updated: Jan 21, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

15.9K
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

12.4K

Area of Science:

  • Hematology
  • Immunology
  • Pathophysiology

Background:

  • Platelets are traditionally known for hemostasis but are increasingly implicated in inflammatory processes.
  • Experimental data reveal significant interactions between thrombosis, hemostasis, and inflammation.

Purpose of the Study:

  • To review the multifaceted roles of platelets in inflammation, coagulation, and tissue remodeling.
  • To discuss the intersection points between hemostasis, thrombosis, and inflammation.

Main Methods:

  • Review of experimental data from mouse and human studies.
  • Detailed discussion of the intrinsic coagulation pathway and platelet-complement interactions.

Main Results:

  • Platelet activation initiates the intrinsic coagulation cascade, influencing wound healing, thrombus formation, and disease pathophysiology.
  • Factor XII (FXII) links platelet activation to the coagulation cascade in immune reactions, modulating inflammation.
  • Platelets possess complement receptors and play a role in tissue remodeling after injury.

Conclusions:

  • Platelets are critical players in inflammation and tissue repair, extending beyond their hemostatic functions.
  • Understanding platelet biology offers potential for novel therapeutic strategies in diseases associated with platelet abundance.