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[Induction of hypercholesterolemia in the rabbit with semisynthetic diets. Changes in the composition of high density
F J Sánchez-Muniz1, A H Terpstra
1Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
Abstract:
The effects on HDL, cholesterol and apoprotein (apo) AI and E contents in New Zealand rabbits fed on casein or soybean protein were studied. The switch from a commercial diet to the semisynthetic diets produced in only 24 hours a cholesterol enrichment of HDL in both groups, being much greater in the group receiving casein. A parallel increase on cholesterol and proteins in HDL in both dietary treatments was noted after 7 days. Apo AI content increased more in the casein group than in the one fed on soybean protein. Apo E increased 100% in the casein lot, while it did not change or tended to diminish in the soya-group. Results suggest an increase formation of HDL rich in apo E as a metabolic response to hypercholesterolemia due to feeding rabbits casein.
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