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Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion
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Structure and Stability of High CaO- and P2O5-Containing Silicate and Borosilicate Bioactive Glasses
Sakthi Prasad, Anuraag Gaddam1, Anuradha Jana
1Department of Materials and Ceramic Engineering, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal.
The Journal of Physical Chemistry. B
|August 13, 2019
Summary
This study investigates bioactive glasses with varying boron content, revealing that boron incorporation enhances antibacterial properties and cell proliferation. Despite reduced thermal stability, these boron-modified glasses show promise for hard tissue engineering applications.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Glass Chemistry
Background:
- Bioactive glasses are crucial for hard tissue regeneration.
- Understanding the structure-property relationship is key to optimizing biomaterial performance.
- Boron's role in silicate glasses for biomedical applications requires further elucidation.
Purpose of the Study:
- To elucidate the structure of novel bioactive glasses with varying boron oxide (B2O3) content.
- To establish a correlation between the glass structure and its thermal stability.
- To evaluate the bioactivity, cell compatibility, and antibacterial properties of these glasses.
Main Methods:
- Synthesis of bioactive glasses with compositions (50.0 - x)SiO2-xB2O3-9.3Na2O-37CaO-3.7P2O5 (x = 0.0, 12.5, 25, 37.5).
- Structural characterization using Raman and magic angle spinning (MAS)-nuclear magnetic resonance (NMR) spectroscopies (29Si, 31P, 11B, 23Na).
- Thermal stability assessment via differential scanning calorimetry (DSC).
Main Results:
- Incorporation of B2O3 led to the formation of QSi4(3B) units and both three- and four-coordinated boron species (BIII, BIV).
- Phosphate species primarily existed as isolated orthophosphate (QP0) units.
- Boron incorporation increased cross-linking but decreased glass thermal stability (ΔT).
Conclusions:
- Boron-modified bioactive glasses exhibit enhanced in vitro apatite-forming ability and cell compatibility.
- Improved bactericidal action against *Escherichia coli* was observed in borosilicate glasses.
- Controlled release of borate ions enhances cell proliferation and antibacterial properties, making them promising for hard tissue engineering.
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