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Updated: Jan 21, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
576
Malignancies in systemic lupus erythematosus: an update.
Alexandra Ladouceur1, Ann E Clarke2, Rosalind Ramsey-Goldman3
1Division of Internal Medicine, Department of Medicine, University of Montreal, Montreal, Quebec.
Current Opinion in Rheumatology
|August 13, 2019
Summary
Systemic lupus erythematosus (SLE) patients show altered cancer risks, with higher rates of some cancers and lower rates of others like breast and prostate cancer. Research is exploring the underlying mechanisms and potential new therapies.
Area of Science:
- Rheumatology
- Oncology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is an autoimmune disease associated with distinct patterns of malignancy.
- Understanding these altered cancer risks is crucial for patient management and research.
Purpose of the Study:
- To review recent literature on malignancy risk in SLE patients.
- To summarize proposed mechanisms for altered cancer susceptibilities in SLE.
Main Methods:
- Literature review of recent studies on SLE and cancer risk.
- Analysis of proposed pathogenetic mechanisms for observed cancer patterns.
Main Results:
- Confirmed increased risks for hematological, lung, thyroid, liver, cervical, and vulvovaginal cancers.
- Confirmed decreased risks for breast and prostate cancers.
- Proposed mechanisms include cytokine activity, viral factors, lupus autoantibodies, and protein downregulation.
Conclusions:
- Recent data reinforce altered malignancy rates in SLE.
- Mechanisms of cancer development in SLE are being elucidated, but further research is needed.
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