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Updated: Jan 21, 2026

Electroporation of Craniofacial Mesenchyme
Published on: November 28, 2011
Preliminary Analysis From the Craniofacial Collaboration United Kingdom Developmental Outcomes in Children With
Helen Care1, Patrick Kennedy-Williams1, Alexandra Cunliffe2
1Oxford Craniofacial Unit, Oxford University Hospitals NHS Foundation Trust.
Insights
Most children with sagittal synostosis treated surgically show average development and behavior. However, parental concerns about conduct and hyperactivity were noted, suggesting potential issues as children age.
Area of Science:
- Pediatric Surgery
- Developmental Pediatrics
- Craniofacial Surgery
Background:
- The Craniofacial Collaboration United Kingdom (CC-UK) network was established in 2015.
- This study analyzes the first wave of data from children aged 3 years with sagittal synostosis undergoing primary corrective surgery.
Purpose of the Study:
- To assess developmental and behavioral outcomes in young children post-craniofacial surgery for sagittal synostosis.
- To identify parental concerns regarding development and behavior in this cohort.
Main Methods:
- Utilized a comprehensive and homogenous dataset from the CC-UK.
- Collected parental measures of child development and behavior for 3-year-olds with treated sagittal synostosis.
Main Results:
- The majority of children were rated by parents within one standard deviation of the mean for development and behavior.
- Conduct and hyperactivity were areas of greatest parental concern, with 24% in the clinically significant range.
- Significant differences in mean scores were observed between the sagittal synostosis group and normative data across 5 of 6 behavioral domains.
Conclusions:
- While most children demonstrate average outcomes, a trend suggests potential for increased developmental difficulties with age.
- Behavioral concerns, particularly conduct and hyperactivity, warrant further investigation.
- Longitudinal research is needed to confirm findings and explore underlying mechanisms driving these outcomes.
Abstract:
The Craniofacial Collaboration United Kingdom (CC-UK) was established across the 4 Highly Specialized Craniofacial Centres (HSCCs) in the UK in 2015. This is the first wave of data to be analyzed, looking at 3-year-old children with sagittal synostosis who have had primary corrective surgery. This is a comprehensive, homogenous dataset, looking at parental measures of development and behavior. The results indicate that the majority of children are rated by their parents as falling within one standard deviation of the mean for both developmental and behavioral measures. However, there was a trend across the age groups within the sample which, although not statistically significant, indicates that more developmental difficulties may become apparent as children get older. Behavior was rated as more problematic, and the areas of greatest parental concern were Conduct (challenging or confrontational behavior) and Hyperactivity domains, where 24% of children were rated as within the clinically significant range. Although the majority of children were rated as falling within the average range, the difference in the mean between the sagittal and the normative group was significant in 5 of the 6 behavioral domains. Further research is required to examine whether these findings are stable over time and to look at the mechanism which might be driving these changes. It is anticipated that future CC-UK analysis will elucidate this more clearly.
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