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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Structure01:45

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Liver Histology01:27

Liver Histology

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Related Experiment Video

Updated: Jan 21, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

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Delayed Graft Function in Simultaneous Liver Kidney Transplantation.

Sharon R Weeks1, Xun Luo1, Christine E Haugen1

  • 1Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Transplantation
|August 13, 2019
PubMed
Summary

Delayed graft function (DGF) in simultaneous liver kidney (SLK) transplants is common and linked to worse outcomes. Key risk factors include pretransplant dialysis and donor characteristics, highlighting areas for potential prevention strategies.

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Area of Science:

  • Nephrology
  • Transplantation immunology
  • Organ transplantation

Background:

  • Delayed graft function (DGF) is a known complication in kidney transplantation.
  • DGF is associated with poorer long-term outcomes after kidney transplants.
  • Simultaneous liver kidney (SLK) transplantation presents unique challenges regarding DGF.

Purpose of the Study:

  • To investigate the incidence of DGF in SLK recipients.
  • To identify specific risk factors associated with DGF in this population.
  • To evaluate the impact of DGF on posttransplant outcomes, including graft failure and mortality.

Main Methods:

  • Analysis of 6214 adult SLK recipients from the Scientific Registry of Transplant Recipients (2002-2017).
  • Poisson multivariate regression to identify risk factors for DGF.
  • Cox proportional hazard analysis to assess the association between DGF and graft failure/mortality.

Main Results:

  • The overall incidence of DGF was 21.8%.
  • Risk factors for DGF in hepatitis C virus (HCV)-negative recipients included pretransplant dialysis, donor BMI, donation after circulatory death, and imported donor organs.
  • DGF significantly increased the risk of kidney graft failure (aHR 2.63), liver graft failure (aHR 1.62), and mortality (aHR 1.62).

Conclusions:

  • Pretransplant dialysis and kidney graft quality are significant risk factors for DGF in HCV-negative SLK recipients.
  • DGF is consistently associated with inferior posttransplant outcomes, irrespective of HCV status.
  • Identifying and mitigating DGF risk factors can improve outcomes for SLK transplant recipients.