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Updated: Jan 21, 2026

Rapid Isolation of Human Breast Milk-Derived Extracellular Vesicles
Published on: November 14, 2025
Transfer of Candesartan Into Human Breast Milk
Elle Dagmar Coberger1, Berit Packert Jensen, Judith Maree Dalrymple
1Department of Clinical Pharmacology, Christchurch Hospital, and the Department of Toxicology, Specialist Biochemistry, Canterbury Health Laboratories, Christchurch, New Zealand.
Background:
There are currently no data regarding the transfer of candesartan into human milk. This report provides data on this transfer, an estimation of the amount breastfed infants receive, and plasma concentrations from two breastfed infants.
Cases:
Three breastfeeding mothers, all stabilized on candesartan (8-32 mg/d), provided milk and plasma samples over one dosing interval (24 hours). Two infant plasma samples were obtained. The amount the infants ingested was estimated to be 0.09% (95% CI 0.07-0.11) of the maternal dose (weight-adjusted). Candesartan was undetectable (less than 0.2 micrograms/L) in infant plasma samples.
Conclusion:
A relative infant dose of 0.09% suggests that maternal benefit from candesartan at standard therapeutic doses may outweigh risk in breastfeeding healthy, term infants.
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