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A wide range gate data acquisition for diagnosing coronary artery disease

Daehyeon Lee1, Sungjoo Yoo2, Dong-Bin Kim3

  • 1Department of Electrical Engineering, Pohang University of Science and Technology, Pohang, Korea.

Echocardiography (Mount Kisco, N.Y.)
|August 13, 2019
PubMed

Insights

This study introduces a new ultrasound method for diagnosing coronary artery disease (CAD). Wide Range Gate (WRG) ultrasound effectively detects vibrations caused by stenosis, showing promise as an initial diagnostic tool.

Area of Science:

  • Cardiovascular Ultrasound
  • Medical Diagnostics
  • Biomedical Engineering

Background:

  • Blood flow turbulence from coronary artery stenosis generates vibrations.
  • These vibrations impact surrounding coronary artery tissue and the adjacent myocardial wall.
  • Investigating novel diagnostic methods for coronary artery disease (CAD) is crucial.

Purpose of the Study:

  • To evaluate the diagnostic feasibility of a novel Wide Range Gate (WRG) ultrasound data acquisition method.
  • To assess WRG ultrasound's capability in detecting high-frequency vibrations indicative of coronary artery stenosis.
  • To establish WRG ultrasound as a potential initial diagnostic tool for CAD.

Main Methods:

  • Utilized a Verasonics ultrasound system for WRG data acquisition.
  • Conducted clinical trials on 80 subjects with suspected CAD.
  • Performed WRG data acquisition prior to coronary angiography (CAG) for comparison.

Main Results:

  • WRG data analysis demonstrated 80% sensitivity and 84% specificity compared to CAG.
  • Specific diagnostic performance varied by artery: LAD (81% sensitivity, 79% specificity), LCx (75% sensitivity, 89% specificity), RCA (85% sensitivity, 82% specificity).
  • Positive vibrometry results were identified as an independent predictive factor for CAD in multivariate analysis.

Conclusions:

  • A new ultrasound-based diagnostic method for CAD was proposed.
  • The WRG data acquisition method shows significant potential as an initial screening tool for coronary artery disease.
  • Further validation may establish WRG ultrasound as a valuable non-invasive diagnostic approach.
Abstract

Keywords:
coronary artery stenosisdoppler vibrometryechocardiography

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