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Compositional Persistence in a Multicyclic Network of Synthetic Replicators.

Jürgen Huck¹, Tamara Kosikova¹, Douglas Philp¹

¹School of Chemistry and EaStCHEM , University of St Andrews , North Haugh , St Andrews , Fife KY16 9ST , U.K.

Journal of the American Chemical Society

|August 13, 2019

Summary

This summary is machine-generated.

Researchers created a chemical reaction network that mimics early life. The network

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Area of Science:

* Origin of life studies
* Chemical systems biology
* Network theory

Background:

* Self-sustaining reaction networks are proposed as a mechanism for the origin of life.
* These networks often involve replication and catalysis of chemical entities.

Purpose of the Study:

* To create and analyze a functional reaction network with self-sustaining properties.
* To investigate how external inputs (templates) affect network composition and behavior.
* To understand the persistence of network structure and its implications for adaptation.

Main Methods:

* Synthesized a reaction network from pairwise combinations of four reagents.
* Introduced preformed templates to observe network responses.
* Conducted serial transfer experiments to assess system variability.
* Utilized kinetic simulations to trace the origin of network persistence.

Main Results:

* A functional reaction network was established, maintaining replicator structures via auto- and cross-catalysis.
* Addition of templates induced network-level compositional changes.
* Network connectivity and catalytic relationships limited induced compositional variability.
* Kinetic simulations identified ternary complexes as key to network persistence.

Conclusions:

* The study demonstrates a persistent chemical reaction network structure independent of continuous selection pressure.
* Network connectivity limits adaptability and evolution in the absence of selection.
* Findings provide insights into the stability of early chemical systems and the emergence of life.