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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Published on: July 19, 2019

Exercise-induced lactate responses in Multiple Sclerosis: A retrospective analysis.

Charly Keytsman¹, Dominique Hansen¹, Inez Wens¹

¹REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.

Neurorehabilitation

|August 13, 2019

Summary

Persons with Multiple Sclerosis (MS) show elevated resting lactate, but exercise lactate levels are similar to healthy controls. Moderate-intensity exercise training reduced lactate accumulation in MS, while high-intensity training did not.

Keywords:

Multiple sclerosis endurance training interval training lactate rehabilitation

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Evaluation of Blood Lactate and Plasma Insulin During High-intensity Exercise by Antecubital Vein Catheterization

Published on: May 18, 2018

Area of Science:

Exercise Physiology
Neurology
Biochemistry

Background:

Individuals with Multiple Sclerosis (MS) exhibit higher resting serum lactate levels compared to healthy controls (HC).
Understanding lactate dynamics during exercise in MS is crucial for optimizing rehabilitation strategies.

Purpose of the Study:

To compare lactate concentrations during acute exercise and after training interventions in MS patients versus HC.
To investigate the effects of different exercise intensities on lactate accumulation in MS.

Main Methods:

Retrospective analysis of lactate concentrations from two prior studies involving submaximal and maximal exercise tests.
Evaluation of lactate levels before and after 24-week mild-to-moderate intensity or 12-week high-intensity interval training interventions in MS patients.

Main Results:

Resting lactate was significantly elevated in MS patients compared to HC.
Submaximal exercise lactate accumulation decreased significantly after mild-to-moderate intensity training in MS.
Maximal exercise lactate levels were similar between MS and HC, and high-intensity training did not yield significant improvements.

Conclusions:

Lactate concentrations during acute submaximal and maximal exercise are comparable between MS patients and HC.
Moderate-intensity exercise training may improve lactate metabolism in MS, whereas high-intensity training shows no significant benefit in this regard.