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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Corneal deflection amplitude and visual field progression in primary open-angle glaucoma.
Younhea Jung1, Heejeong Chun1, Jung Il Moon1
1Department of Ophthalmology, College of Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Plos One
|August 13, 2019
Summary
Higher corneal deflection amplitude is linked to faster visual field progression in primary open-angle glaucoma (POAG) patients. This finding highlights corneal biomechanics as a factor in glaucoma progression.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Corneal Biomechanics
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Understanding factors influencing glaucoma progression is crucial for patient management.
- Corneal properties may play a role in the biomechanical response of the eye.
Purpose of the Study:
- To investigate the relationship between corneal deflection amplitude and visual field progression rate in POAG patients.
- To determine if corneal biomechanics are associated with the rate of glaucoma damage.
Main Methods:
- 113 eyes of 65 POAG patients were followed for an average of 4.81 years.
- Visual field progression rate was assessed using standard automated perimetry.
- Corneal deflection amplitude was measured with Corvis ST; linear mixed models analyzed relationships with intraocular pressure (IOP) and progression.
Main Results:
- Higher intraocular pressure (IOP) and greater corneal deflection amplitude were significantly associated with faster visual field progression.
- Eyes with higher IOP and greater deflection amplitude demonstrated accelerated glaucoma progression.
- Both univariate and multivariate analyses confirmed these significant associations.
Conclusions:
- Corneal deflection amplitude is significantly related to glaucoma progression in POAG.
- Increased corneal deflection amplitude is a predictor of faster visual field progression in POAG patients.
- Corneal biomechanical properties should be considered in the assessment of glaucoma progression.
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