The preference for future outcomes correlates with the temporal variability of functional connectivity among brain...

People inevitably make decisions between short-term and long-term consequences across domains like education, health and economics. In this kind of decision, the tendency to discount the value of later-larger rewards with increasing delays is defined as delay discounting (DD). A recent review has suggested that three neural systems which respectively responsible for valuation, prospection and cognitive control (e.g., ventromedial prefrontal cortex [vmPFC], hippocampus, precuneus and dorsolateral prefrontal cortex [dlPFC]) could interact with each other flexibly to have impacts on DD. However, to date, there is little attention paid on the connection between the DD and the dynamic interaction of brain regions.To tackle this issue, we investigate the relationship between the DD and the time-varying connectivity among brain regions in two samples of young adults. Results in sample 1 found that the DD was negatively correlated with the temporal variability of functional connectivity [FC] between the vmPFC and precuneus, and between the vmPFC and the left superior frontal gyrus. And the temporal variabilities of FC between the ventral striatum and right dlPFC, and between the ventral striatum and dorsomedial prefrontal cortex were also negatively related to DD. Furthermore, the main results were well replicated and validated in another sample using different analysis parameters. Overall, our findings reveal that temporal fluctuation of FC within default mode and fronto-striatal circuits can favor for prospecting future, cognitive control and valuation of delayed incentives, and this flexible connectivity patterns generally have association with preference for future outcomes.