Related Experiment Video
Updated: Jan 21, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Seasonal Variation of Duodenal Intraepithelial Lymphocytosis
Amnon Sonnenberg1, Kevin O Turner2, Robert M Genta3
1Division of Gastroenterology, Portland VA Medical Center and Oregon Health & Science University, Portland, Oregon.
Abstract:
The increase of intraepithelial lymphocytes in architecturally normal duodenal mucosa is commonly referred to as duodenal intraepithelial lymphocytosis (DIL). The characteristic appearance of DIL corresponds with Marsh grade 1, that is, normal or mild increase in lamina propria inflammation of the duodenal mucosa, with no crypt hyperplasia or villous atrophy.1 Approximately 11% of DIL patients harbor clinical and serologic features suggestive of gluten sensitivity.2 An additional 2% of patients with DIL harbor concomitant microscopic colitis.3Helicobacter pylori gastritis may contribute to another 10%-15% of DIL, which may resolve following eradication of H pylori.4 In the majority of cases with DIL, however, its underlying cause has remained unknown.1 A study of the seasonal variations in the occurrence of DIL may provide additional clues about its yet unknown etiology.
Related Concept Videos
Seasoning of Wood
Achieving equilibrium moisture content is the goal of seasoning; this is the point where the wood's moisture content stabilizes to align with the moisture levels of the surrounding environment. Proper...
What is Variation?
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
Biological Clocks and Seasonal Responses
Variation
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Variation of Atmospheric Pressure
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...

