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Updated: Jan 21, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
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Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

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Coumarin-containing hybrids and their anticancer activities

Longfei Zhang1, Zhi Xu2

  • 1Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.

European Journal of Medicinal Chemistry
|August 13, 2019
PubMed

Insights

Novel coumarin-containing hybrids show promise as anticancer agents, offering new mechanisms to combat drug resistance and reduce side effects in cancer treatment.

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Drug Discovery

Background:

  • Cancer is a leading global cause of death, necessitating novel therapeutic strategies.
  • Drug resistance and severe side effects limit current anticancer treatments.
  • The coumarin scaffold is a versatile natural product motif with demonstrated antiproliferative activity.

Purpose of the Study:

  • To review recent advances in the development of coumarin-containing hybrids as anticancer agents.
  • To explore structure-activity relationships and mechanisms of action for these compounds.
  • To highlight the potential of coumarin hybrids in overcoming cancer drug resistance.

Main Methods:

  • Literature review of studies published between 2015 and 2019.
  • Analysis of structure-activity relationships (SAR) of coumarin hybrids.
  • Discussion of diverse antiproliferative mechanisms exhibited by coumarin derivatives.

Main Results:

  • Coumarin hybrids demonstrate significant antiproliferative effects against various cancer types.
  • Hybridization strategies can enhance efficacy and reduce toxicity compared to parent compounds.
  • Emerging evidence supports coumarin hybrids as potential agents against multidrug-resistant cancers.

Conclusions:

  • Coumarin-containing hybrids represent a promising class of novel anticancer agents.
  • These hybrids offer potential for improved therapeutic interventions by addressing drug resistance and side effects.
  • Further research into coumarin hybrids is warranted for their clinical application in cancer therapy.
Keywords:
AnticancerCoumarinHybrid moleculesMechanism of actionStructure-activity relationship

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