Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hybrid Zones

Hybrid Zones

Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.

Hybridization of Atomic Orbitals I

Hybridization of Atomic Orbitals I

The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...

Hybridization of Atomic Orbitals II

Hybridization of Atomic Orbitals II

sp3d and sp3d 2 Hybridization

In-situ Hybridization

In-situ Hybridization

In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...

IR Absorption Frequency: Hybridization

IR Absorption Frequency: Hybridization

Hydrocarbons such as alkanes, alkenes, and alkynes show characteristic C–H stretching absorption bands. These IR stretching frequencies depend on the hybridization of the involved carbon atom and can be explained in terms of the s character of each hybridized atomic orbital.
Among the sp, sp2, and sp3 hybridized orbitals, sp orbitals have the maximum s character (50%). Consequently, the electrons are held more closely to the nucleus, resulting in stronger and shorter C–H bonds that...

Resonance and Hybrid Structures

Resonance and Hybrid Structures

According to the theory of resonance, if two or more Lewis structures with the same arrangement of atoms can be written for a molecule, ion, or radical, the actual distribution of electrons is an average of that shown by the various Lewis structures.
Resonance Structures and Resonance Hybrids
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N–O and N=O bonds.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Factors Influencing Fresh Mother's Own Milk Feeding Frequency in Very Low Birth Weight Infants: A Retrospective Study.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2026

Same author

Molecular Insights into the Transition from Elastohydrodynamic to Boundary Lubrication: Unveiling Mechanistic Changes.

Langmuir : the ACS journal of surfaces and colloids·2026

Same author

CAV1 up-regulated by peste des petits ruminants virus nucleocapsid protein impairs type I IFN response by cholesterol synthesis.

Veterinary microbiology·2026

Same author

Genomic contraction of the <i>LOX</i> gene family limits jasmonic acid biosynthesis and contributes to delayed flower bud opening in honeysuckle (<i>Lonicera japonica</i>).

Horticulture research·2026

Same author

Widely targeted metabolomics reveals organ-specific metabolite accumulation and functional differentiation of leaves, pulp and seeds in wild jujube (Ziziphus jujuba var. spinosa).

BMC plant biology·2026

Same author

Synergistic effect and resistance prevention activity of antimicrobial peptide MPX with Tulathromycin against <i>Actinobacillus pleuropneumoniae</i>.

Frontiers in microbiology·2026

Search research articles

Related Experiment Video

Updated: Jan 21, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Coumarin-containing hybrids and their anticancer activities.

Longfei Zhang¹, Zhi Xu²

¹Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.

European Journal of Medicinal Chemistry

|August 13, 2019

Summary

Novel coumarin-containing hybrids show promise as anticancer agents, offering new mechanisms to combat drug resistance and reduce side effects in cancer treatment.

Keywords:

Anticancer Coumarin Hybrid molecules Mechanism of action Structure-activity relationship

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Assessing Specificity of Anticancer Drugs In Vitro

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Related Experiment Videos

Last Updated: Jan 21, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Assessing Specificity of Anticancer Drugs In Vitro

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Area of Science:

Medicinal Chemistry
Pharmacology
Drug Discovery

Background:

Cancer is a leading global cause of death, necessitating novel therapeutic strategies.
Drug resistance and severe side effects limit current anticancer treatments.
The coumarin scaffold is a versatile natural product motif with demonstrated antiproliferative activity.

Purpose of the Study:

To review recent advances in the development of coumarin-containing hybrids as anticancer agents.
To explore structure-activity relationships and mechanisms of action for these compounds.
To highlight the potential of coumarin hybrids in overcoming cancer drug resistance.

Main Methods:

Literature review of studies published between 2015 and 2019.
Analysis of structure-activity relationships (SAR) of coumarin hybrids.
Discussion of diverse antiproliferative mechanisms exhibited by coumarin derivatives.

Main Results:

Coumarin hybrids demonstrate significant antiproliferative effects against various cancer types.
Hybridization strategies can enhance efficacy and reduce toxicity compared to parent compounds.
Emerging evidence supports coumarin hybrids as potential agents against multidrug-resistant cancers.

Conclusions:

Coumarin-containing hybrids represent a promising class of novel anticancer agents.
These hybrids offer potential for improved therapeutic interventions by addressing drug resistance and side effects.
Further research into coumarin hybrids is warranted for their clinical application in cancer therapy.