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Updated: Jan 21, 2026
11:13
Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
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Systems Approach to Study Associations between OxLDL and Abdominal Aortic Aneurysms
Łukasz Gutowski1, Kaja Gutowska2,3, Maria Pioruńska-Stolzmann1
1Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, Poland.
International Journal of Molecular Sciences
|August 14, 2019
Summary
Oxidized low-density lipoprotein (oxLDL) impacts over half of the processes involved in abdominal aortic aneurysm (AAA) development. However, oxLDL
Area of Science:
- Vascular Biology
- Biochemistry
- Systems Biology
Background:
- Abdominal aortic aneurysm (AAA) is a prevalent vascular disease with high mortality.
- The precise pathogenesis of AAA remains incompletely understood.
- Low-density lipoprotein (LDL) and its oxidized form (oxLDL) are implicated in vascular diseases.
Purpose of the Study:
- To investigate the impact of oxidized low-density lipoprotein (oxLDL) on abdominal aortic aneurysm (AAA) development.
- To model the role of oxLDL in AAA pathogenesis using Petri-nets.
Main Methods:
- Development of two Petri-net models: a full model including LDL oxidation and a reduced model without it.
- Analysis of models using t-invariants to identify stable subprocesses.
- Application of knockout analysis to assess the criticality of individual subprocesses.
Main Results:
- Oxidized low-density lipoprotein (oxLDL) was found to influence 55.84% of subprocesses related to AAA development in the models.
- Knockout analysis and simulation indicated a negligible impact of oxLDL on AAA enlargement and rupture.
Conclusions:
- While oxLDL affects a significant portion of AAA-related subprocesses, its direct contribution to AAA expansion and rupture appears minimal.
- Further research is needed to fully elucidate the complex pathogenesis of AAA.
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