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Updated: Jan 21, 2026

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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
6.3K
HPV-Related Multiphenotypic Sinonasal Carcinoma: A Unique Case
Daniel Ching1, Shadi Pirasteh2, Chanh Ly2
1Fiona Stanley Hospital, Perth, Western Australia, Australia.
International Journal of Surgical Pathology
|August 14, 2019
Summary
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a rare sinonasal tumor. Despite high-grade features, HMSC shows indolent behavior, necessitating accurate diagnosis to differentiate it from mimickers for proper management.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), formerly HPV-related carcinoma with adenoid cystic carcinoma-like features, is a distinct sinonasal neoplasm.
- HMSC exhibits a combination of surface-derived and salivary gland carcinoma features, linked to high-risk HPV, particularly HPV type 33.
Observation:
- Most HMSC cases present with high-grade histologic characteristics.
- Paradoxically, HMSC demonstrates relatively indolent clinical behavior.
Findings:
- Accurate differentiation of HMSC from histologic mimics is crucial.
- Management and prognosis differ significantly between HMSC and similar-appearing tumors.
Implications:
- This review highlights a unique HMSC case and discusses its clinical significance.
- Understanding HMSC's distinct features aids in appropriate patient management and prognostic assessment.
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