Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleus01:32

The Nucleus

100.7K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
100.7K
The Nucleus01:25

The Nucleus

7.3K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
7.3K
What are Cells?01:07

What are Cells?

197.2K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
197.2K
Case Studies01:22

Case Studies

13.3K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
13.3K
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

288
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
288
Longitudinal Studies01:26

Longitudinal Studies

481
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
481

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioluminescent xenograft model of acute myeloid leukemia for immunotherapy preclinical studies.

Leukemia research·2026
Same author

TREX2 component PCID2 scaffolds alternative SAC3-based subcomplexes with distinct RNA processing and export function.

bioRxiv : the preprint server for biology·2026
Same author

The γ-Tubulin Ring Complex promotes mitotic spindle integrity and acts as a microtubule minus-end cap during mitosis.

bioRxiv : the preprint server for biology·2026
Same author

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm.

Nature cell biology·2025
Same author

A genome-wide RNAi screen for novel CIN genes using human artificial chromosome.

PNAS nexus·2025
Same author

Auxin-induced depletion of human CCR4-NOT subunits reveals opposing functions of CNOT1 and CNOT4 in mRNA metabolism.

The Journal of biological chemistry·2025

Related Experiment Video

Updated: Jan 21, 2026

In-Nucleus Hi-C in Drosophila Cells
11:58

In-Nucleus Hi-C in Drosophila Cells

Published on: September 15, 2021

4.7K

The cell nucleus. A study in Burgundy.

Oleg Demidov1,2, Vasilisa Aksenova3, Mary Dasso3

  • 1a INSERM UMR1231, Laboratory of Excellence LipSTIC, University of Burgundy Franche-Comté , Dijon , France.

Nucleus (Austin, Tex.)
|August 14, 2019
PubMed
Summary

Wilhelm Bernhard

Keywords:
Phase separationlaminsnuclear poresnucleolus

More Related Videos

Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice
09:06

Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice

Published on: July 14, 2022

2.0K
Assessment of Zebrafish Lens Nucleus Localization and Sutural Integrity
07:16

Assessment of Zebrafish Lens Nucleus Localization and Sutural Integrity

Published on: May 6, 2019

9.0K

Related Experiment Videos

Last Updated: Jan 21, 2026

In-Nucleus Hi-C in Drosophila Cells
11:58

In-Nucleus Hi-C in Drosophila Cells

Published on: September 15, 2021

4.7K
Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice
09:06

Measurement of the Compressibility of Cell and Nucleus Based on Acoustofluidic Microdevice

Published on: July 14, 2022

2.0K
Assessment of Zebrafish Lens Nucleus Localization and Sutural Integrity
07:16

Assessment of Zebrafish Lens Nucleus Localization and Sutural Integrity

Published on: May 6, 2019

9.0K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Microscopy

Background:

  • Wilhelm Bernhard pioneered microscopy, proposing nuclear compartmentalization.
  • He identified nuclear bodies and peri-chromatin fibrils containing RNA.
  • His work laid the foundation for understanding nuclear organization.

Purpose of the Study:

  • To review advancements in nuclear compartmentalization.
  • To emphasize the cell nucleus as a hub of specialized colloidal compartments.
  • To discuss the orchestration of replication, transcription, and nuclear transport.

Main Methods:

  • Review of historical microscopy techniques.
  • Discussion of nuclear body and peri-chromatin fibril characterization.
  • Synthesis of findings from a scientific workshop.

Main Results:

  • Reiteration of Bernhard's hypothesis on specialized nuclear compartments.
  • Confirmation of RNA presence in nuclear granules.
  • Emphasis on the nucleus as a dynamic hub for key cellular processes.

Conclusions:

  • The cell nucleus functions as a hub of specialized colloidal compartments.
  • These compartments are crucial for regulating replication, transcription, and nuclear transport.
  • Continued research and workshops honor Bernhard's legacy in nuclear biology.