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Related Experiment Video

Updated: Jan 21, 2026

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
11:35

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

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Cutaneous Lymphomas.

L Specht1, L Skov2

  • 1Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|August 14, 2019
PubMed
Summary
This summary is machine-generated.

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Primary cutaneous lymphomas, often T-cell lymphomas, primarily affect the skin and typically have an indolent course. Skin-directed therapies are the main treatment for these lymphomas.

Area of Science:

  • Oncology
  • Dermatology
  • Hematology

Background:

  • Primary cutaneous lymphomas (PCLs) are the second most common extra-nodal lymphomas.
  • They are predominantly T-cell lymphomas with a typically indolent clinical course.
  • Mycosis fungoides is the most prevalent type of PCL.

Purpose of the Study:

  • To review the characteristics and treatment strategies for primary cutaneous lymphomas.
  • To highlight the efficacy of skin-directed therapies for early-stage disease.
  • To discuss the role of systemic treatments and emerging therapies for advanced PCLs.

Main Methods:

  • Review of literature on primary cutaneous lymphomas.
  • Discussion of epidemiological and clinical characteristics.
  • Analysis of treatment modalities, including skin-directed and systemic therapies.
Keywords:
Cutaneous lymphomasdiagnosisprognosisskin-directed therapysystemic therapytherapy

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Main Results:

  • PCLs often remain confined to the skin for extended periods.
  • Skin-directed therapies (topical corticosteroids, phototherapy, topical retinoids, topical nitrogen mustard, radiation) are the mainstay of treatment.
  • Radiation therapy, including total skin electron beam therapy, is highly effective for localized disease.

Conclusions:

  • Skin-directed therapies are the primary treatment for PCLs, with radiation therapy being crucial for localized disease.
  • Systemic treatments are reserved for cases with extra-cutaneous spread, often in combination with skin-directed approaches.
  • Advances in immunotherapy hold promise for improving outcomes in cutaneous lymphomas.