The relationship between mean platelet volume and albuminuria in patients with type 2 diabetes mellitus
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Published on: February 28, 2013
Manal Khudder Abdul Razak1, Ammar Moyad Akif2, NawarMoezAl Nakeeb3
1University of Baghdad, Baghdad College of Medicine, Department of Medicine, Baghdad, Iraq.
Background&Aim:
Mean platelet volume (MPV) is suggested as a marker of platelet reactivity and tendency for thrombosis and microvascular complications like albuminuria in patients with type 2 DM. We aimed to measure the MPV in patients with type 2 DM and its correlation with albuminuria, body mass index (BMI), duration of DM, hypertension (HTN), stroke, ischemic heart disease (IHD), and HbA1c level.
Methods:
A cross sectional study included 100 patients with type 2 DM ≥ 18 y of both genders who were randomly selected from the medical units of Baghdad Teaching Hospital. After taking verbal consents; MPV was measured&correlated with aimed variables. Diabetics with HbA1c ≤ 7% were considered as having adequate control while those with (HbA1c) > 7% as having poor control. Albumin creatinine ratio (ACR) in urine was measured and classified into normal, moderately and severely increased. Odds ratios with 95% CI were calculated and P ≤ 0.05 was considered as statistically significant.
Results:
The mean MPV was 7.7 fl ± 1.2. Regarding ACR, 42% had normal level, 37% with moderately increased and 21% had severely increased level. Regarding HbA1c, 68% were having poorly controlled DM. Mean platelets' count and MPV were higher in the uncontrolled group with a statistically significant association. There was a statistically significant positive correlation between MPV and albuminuria, duration of DM, HTN, IHD, Stroke, BMI, HbA1c, and platelets count.
Conclusions:
The mean MPV was statistically significantly higher in the uncontrolled DM group and there was a statistically significant positive correlation between MPV and albuminuria.
Insights
Mean platelet volume (MPV) is elevated in poorly controlled type 2 diabetes and correlates with albuminuria. This suggests MPV may indicate increased risk for diabetic complications.
Area of Science:
- Endocrinology
- Hematology
- Nephrology
Background:
- Mean platelet volume (MPV) is a marker of platelet reactivity.
- MPV may indicate thrombosis and microvascular complications in type 2 diabetes mellitus (DM).
Purpose of the Study:
- To measure MPV in type 2 DM patients.
- To correlate MPV with albuminuria, BMI, DM duration, hypertension, stroke, ischemic heart disease, and HbA1c.
Main Methods:
- Cross-sectional study of 100 type 2 DM patients (age ≥18).
- MPV, HbA1c, and albumin-creatinine ratio (ACR) were measured.
- Correlations were assessed using odds ratios; P ≤ 0.05 was significant.
Main Results:
- Mean MPV was 7.7 fl ± 1.2.
- 68% of patients had poorly controlled DM (HbA1c > 7%).
- Higher MPV correlated significantly with albuminuria, DM duration, hypertension, stroke, IHD, BMI, HbA1c, and platelet count.
Conclusions:
- Mean MPV was significantly higher in uncontrolled type 2 DM.
- MPV showed a significant positive correlation with albuminuria.
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