Related Experiment Video

Updated: Jan 21, 2026

Measuring Phagocytosis of Aspergillus fumigatus Conidia by Human Leukocytes using Flow Cytometry
09:43

Measuring Phagocytosis of Aspergillus fumigatus Conidia by Human Leukocytes using Flow Cytometry

Published on: December 7, 2019

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Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus

Nathan P Wiederhold1, Laura K Najvar2,3, Rosie Jaramillo2,3

  • 1Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA wiederholdn@uthscsa.edu.

Antimicrobial Agents and Chemotherapy
|August 14, 2019
PubMed

Insights

Rezafungin, an investigational echinocandin, improved survival in mice with invasive aspergillosis caused by azole-resistant Aspergillus fumigatus. This new antifungal agent also reduced kidney fungal burden in the study.

Area of Science:

  • Mycology
  • Pharmacology
  • Infectious Diseases

Background:

  • Invasive aspergillosis presents a significant threat, particularly strains resistant to azole antifungals.
  • Developing novel antifungal therapies is crucial for managing challenging infections.

Purpose of the Study:

  • To assess the efficacy of extended-interval dosing of rezafungin against azole-resistant Aspergillus fumigatus.
  • To evaluate rezafungin's impact on survival and fungal burden in a disseminated invasive aspergillosis mouse model.

Main Methods:

  • Mice with invasive aspergillosis were treated with varying doses of rezafungin (1, 4, 16 mg/kg) on days 1, 4, and 7.
  • Survival rates were compared between rezafungin-treated groups, a posaconazole control group, and an untreated group.
  • Quantitative real-time PCR was used to measure kidney fungal burden.

Main Results:

  • Rezafungin treatment significantly improved survival across all tested doses compared to controls.
  • A notable reduction in kidney fungal burden was observed in mice treated with rezafungin.
  • Posaconazole also demonstrated a survival benefit at supratherapeutic doses.

Conclusions:

  • Extended-interval dosing of rezafungin shows promise as a treatment for invasive aspergillosis caused by azole-resistant Aspergillus fumigatus.
  • Rezafungin effectively reduces fungal burden and improves survival, offering a potential new therapeutic option.
Keywords:
Aspergillus fumigatusTR34/L98Hazole resistanceinvasive aspergillosismurine modelrezafungin

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