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Metabolic Disorders and Anesthesia
Cindy Yeoh1, Howard Teng1, Jacob Jackson1
1Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Current Anesthesiology Reports
|August 14, 2019
Summary
Anesthesiologists must understand inborn errors of metabolism for safe perioperative care. This review details common metabolic disorders and their anesthetic management challenges.
Area of Science:
- Anesthesiology
- Medical Genetics
- Biochemistry
Background:
- Metabolic disorders are inherited conditions affecting metabolism.
- These rare disorders present unique perioperative challenges for anesthesiologists.
- Advancements in genomics continually identify new metabolic disorders.
Purpose of the Study:
- To review common metabolic disorders encountered in perioperative medicine.
- To discuss anesthetic considerations and challenges for these conditions.
- To enhance anesthesiologist preparedness for managing patients with metabolic disorders.
Main Methods:
- Literature review of common metabolic disorders.
- Analysis of perioperative anesthetic management strategies.
- Synthesis of current knowledge on inborn errors of metabolism.
Main Results:
- Identified common metabolic disorders including carbohydrate, amino acid, and urea cycle disorders.
- Detailed anesthetic considerations for organic acidemias, mitochondrial, and lysosomal storage disorders.
- Highlighted challenges in managing metal metabolism disorders.
Conclusions:
- Anesthesiologists require specific knowledge of metabolic disorders.
- Perioperative management requires tailored anesthetic approaches.
- Familiarity with these conditions is crucial for patient safety.
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