Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

842
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
842
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.0K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.0K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

15.1K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.1K
Export of Mitochondrial and Chloroplast Genes02:19

Export of Mitochondrial and Chloroplast Genes

4.1K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
4.1K
Epigenetic Regulation01:46

Epigenetic Regulation

33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
GTPases and their Regulation02:14

GTPases and their Regulation

9.8K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology.

Nature communications·2026
Same author

Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia.

PLoS computational biology·2026
Same author

Dietary restriction in aging and longevity.

Nature aging·2026
Same author

Adiponectin and aging: Mechanistic insights, clinical paradox, and therapeutic horizons.

Ageing research reviews·2026
Same author

Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by Aging.

Aging cell·2026
Same author

Acetyl-CoA availability regulates neuronal metabolism, growth, and synaptic activity.

bioRxiv : the preprint server for biology·2026
Same journal

Remodeling the marrow fat niche: BMAT in cancer bone metastases and hematological malignancies.

Current opinion in endocrine and metabolic research·2026
Same journal

Erythropoietin and Skeletal Cells CrossTalks in Physiology and Disease.

Current opinion in endocrine and metabolic research·2026
Same journal

Nutrient uptake and metabolism in osteoblasts.

Current opinion in endocrine and metabolic research·2026
Same journal

Bone Marrow Skeletal Stem Cell Dysfunction: Adipocytes during skeletal aging and senescence.

Current opinion in endocrine and metabolic research·2026
Same journal

Adiponectin expressing skeletal stem/progenitor cells in the bone and bone marrow homeostasis.

Current opinion in endocrine and metabolic research·2025
Same journal

Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers.

Current opinion in endocrine and metabolic research·2024
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

9.9K

Mitochondrial regulator PGC-1a-Modulating the modulator.

Karl N Miller1, Josef P Clark2, Rozalyn M Anderson2,3

  • 1Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Current Opinion in Endocrine and Metabolic Research
|August 14, 2019
PubMed
Summary
This summary is machine-generated.

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) regulates metabolism through multiple pathways. New research explores PGC-1a

More Related Videos

A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
11:43

A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans

Published on: October 16, 2015

10.6K
Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells
09:28

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells

Published on: December 13, 2010

13.2K

Related Experiment Videos

Last Updated: Jan 21, 2026

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

9.9K
A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
11:43

A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans

Published on: October 16, 2015

10.6K
Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells
09:28

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells

Published on: December 13, 2010

13.2K

Area of Science:

  • Metabolic regulation
  • Molecular biology
  • Aging research

Background:

  • Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a key metabolic regulator.
  • PGC-1a integrates various intracellular signaling pathways.
  • Understanding PGC-1a regulation is crucial for metabolic and aging research.

Purpose of the Study:

  • To provide an update on the regulation of PGC-1a.
  • To discuss novel small molecule effectors and their translational potential.
  • To explore PGC-1a's role in aging biology and potential anti-aging interventions.

Main Methods:

  • Review of transcriptional, post-transcriptional, and post-translational regulation of PGC-1a.
  • Analysis of recently identified small molecule modulators of PGC-1a.
  • Examination of PGC-1a's interaction with RNA in transcription and processing.

Main Results:

  • PGC-1a is regulated at multiple molecular levels.
  • Small molecules targeting PGC-1a show translational promise.
  • Novel insights into PGC-1a's RNA interactions impacting gene expression.
  • PGC-1a is implicated as a potential target for anti-aging strategies.

Conclusions:

  • PGC-1a regulation is complex, involving multiple layers of control.
  • Targeting PGC-1a with small molecules offers therapeutic potential.
  • PGC-1a represents a promising candidate for interventions in aging biology.