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Novel Regulators and Targets of Redox Signaling in Pulmonary Vasculature

Zdravka Daneva1, Victor E Laubach2, Swapnil K Sonkusare1,3

  • 1Robert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, 22908, USA.

Current Opinion in Physiology
|August 14, 2019
PubMed

Insights

Pulmonary arterial hypertension (PAH) involves redox signaling. Understanding reactive oxygen species (ROS) modulators and targets in lung cells is key to developing new PAH and lung injury treatments.

Area of Science:

  • Pulmonary vascular biology
  • Redox signaling
  • Pathophysiology of lung diseases

Background:

  • Dysregulated redox signaling in pulmonary vasculature contributes to pulmonary arterial hypertension (PAH) and lung injury.
  • Reactive oxygen species (ROS) production and signaling are critical mediators of cellular effects in the lungs.
  • Understanding ROS modulators and targets is essential for novel therapeutic strategies.

Purpose of the Study:

  • To review recent studies on reactive oxygen species (ROS) modulators and targets in pulmonary endothelial and smooth muscle cells.
  • To discuss the cellular effects of ROS signaling in the context of lung pathologies.
  • To explore the link between dysregulated redox signaling and disease conditions like PAH.

Main Methods:

  • Literature review of recent studies on ROS signaling in pulmonary vasculature.
  • Analysis of cellular effects mediated by ROS modulators and targets.
  • Examination of disease conditions associated with altered redox signaling.

Main Results:

  • Recent studies highlight the central role of redox signaling in PAH development.
  • Specific modulators and targets of ROS have been identified in pulmonary cells.
  • Dysregulated ROS signaling pathways are implicated in lung injury and disease progression.

Conclusions:

  • Targeting ROS modulators and signaling pathways offers potential therapeutic avenues for PAH and lung injury.
  • Further research into the complex redox network in pulmonary vasculature is warranted.
  • A deeper understanding of ROS in lung cells can lead to innovative treatments for respiratory diseases.
Keywords:
Redox signalingendothelial celllung injurypulmonary hypertensionsmooth muscle cell

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