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Updated: Jan 21, 2026
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Visualization and Analysis of Pharyngeal Arch Arteries using Whole-mount Immunohistochemistry and 3D Reconstruction
Published on: March 31, 2020
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[Pharyngeal acid load and different functional endoscopy findings].
F Michel1, R Dannesberger2, T Stroh3
1HNO-Praxis im Kreiskrankenhaus, Hauptstraße 30, 64342, Seeheim-Jugenheim, Deutschland. ohrweh@me.com.
HNO
|August 14, 2019
Summary
Pharyngeal acid exposure is linked to upper esophageal sphincter insufficiency, esophagitis, and gastric heterotopia. Elevated acid levels in the pharynx indicate pathological reflux, potentially causing airway symptoms.
Area of Science:
- Gastroenterology
- Otolaryngology
- Diagnostic Medicine
Background:
- Laryngopharyngeal reflux (LPR) diagnosis is challenging.
- Functional endoscopy reveals various upper aerodigestive tract findings.
- Oropharyngeal pH monitoring aids in assessing acid exposure.
Purpose of the Study:
- To investigate the link between pharyngeal acid exposure and findings on functional endoscopy.
- To evaluate the diagnostic value of functional endoscopy for LPR.
- To explore the pathogenetic relationship between specific endoscopic findings and reflux-associated symptoms.
Main Methods:
- Functional endoscopy of the upper aerodigestive tract.
- Oropharyngeal pH measurement to quantify pharyngeal acid load.
- Correlation analysis between endoscopic findings and pH data.
Main Results:
- Findings like upper esophageal sphincter insufficiency, cardia insufficiency, esophagitis, gastric heterotopia, and axial sliding hernia correlate with pharyngeal acid exposure.
- Significantly increased pharyngeal acid loads were observed in cases of gastric heterotopia and axial sliding hernia.
- Pharyngeal acid load measurements were consistently in the pathological or very pathological range.
Conclusions:
- Functional endoscopy is valuable for diagnosing laryngopharyngeal reflux.
- Gastric heterotopia and axial sliding hernia are associated with high pharyngeal acid loads.
- These findings may contribute to otorhinolaryngologic symptoms, suggesting a pathogenetic link to reflux.
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