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Mitomycin C toxicity and pharmacokinetics in mice given sulfur nucleophiles
R T Dorr1, D S Alberts, J D Liddil
1Department of Medicine, University of Arizona, Tucson 85724.
Anticancer Research
|July 1, 1988
Abstract:
The sulfur nucleophiles, sodium thiosulfate (Na2S2O3) and N-acetylcysteine (NAC) given in maximally tolerated doses did not reduce the hematologic toxicity of high dose mitomycin C (MMC) in normal mice. In addition, neither sulfur nucleophile significantly altered the antileukemic activity of MMC. Pharmacokinetic studies of MMC in normal mice, demonstrated rapid plasma elimination (T1/2 beta = 0.53 hrs) and substantial drug distribution to the bone marrow which was enhanced by NAC. These results demonstrate a lack of MMC antidotal activity for Na2S2O3 and NAC.