Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

4.5K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
4.5K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.6K
Overview
40.6K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

5.0K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.0K
Base Excision Repair01:54

Base Excision Repair

26.1K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.1K
Base Excision Repair01:54

Base Excision Repair

5.0K
5.0K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

7.9K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foundational endovascular concepts and devices for cardiac surgeons.

JTCVS structural and endovascular·2026
Same author

Contemporary Management of the Aortic Arch: A Narrative Review.

Journal of clinical medicine·2026
Same author

The impact of left ventricular assist devices on kidney function: a systematic review and meta-analysis.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same author

From risk to results: Multi-arterial coronary bypass approaches in high-risk cohorts.

Asian cardiovascular & thoracic annals·2026
Same author

Strategies for Aortic Root Measurement in Patients Undergoing Surveillance for Thoracic Aortic Disease.

Journal of clinical medicine·2026
Same author

Clinical, Physiologic, and Anatomic Outcomes of a Novel Bioprosthetic Aortic Valved Conduit.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Jan 21, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.4K

Robotic Extended Right Hemicolectomy with Complete Mesocolic Excision and D3 Lymph Node Dissection.

Irbaz Hameed1, Piyush Aggarwal1, Martin R Weiser2

  • 1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Annals of Surgical Oncology
|August 14, 2019
PubMed
Summary

Robot-assisted surgery enables complete mesocolic excision and D3 lymph node dissection for colon cancer. This minimally invasive approach enhances visualization and dexterity for improved patient outcomes.

More Related Videos

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

1.4K
Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
16:48

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

47.6K

Related Experiment Videos

Last Updated: Jan 21, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.4K
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

1.4K
Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
16:48

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

47.6K

Area of Science:

  • Surgical Oncology
  • Minimally Invasive Surgery
  • Robotic Surgery

Background:

  • Complete mesocolic excision and D3 lymph node dissection are beneficial for colon cancer treatment.
  • Robot-assisted surgery offers potential advantages in complex oncologic resections.

Observation:

  • A 62-year-old male with hepatic flexure adenocarcinoma underwent robot-assisted extended right hemicolectomy.
  • The procedure involved complete mesocolic excision, D3 lymph node dissection, and resection with intact visceral peritoneum.

Findings:

  • The robotic approach facilitated precise dissection along the superior mesenteric vein and en bloc resection of the mesentery and lymph nodes.
  • Indocyanine green fluorescence imaging confirmed adequate perfusion before performing an intracorporeal anastomosis.
  • Pathology revealed T3N0 adenocarcinoma with all negative margins.

Implications:

  • Robotic assistance enhances visualization and instrument dexterity for complete mesocolic excision and D3 lymph node dissection.
  • This technique may improve oncologic outcomes in patients with colon cancer.
  • Robot-assisted surgery represents a viable approach for complex colon cancer resections.