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Childhood gastroparesis is a unique entity in need of further investigation

Liz Febo-Rodriguez1, Bruno P Chumpitazi1, Robert J Shulman1

  • 1Department of Pediatrics, Baylor College of Medicine, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Houston, TX, USA.

Neurogastroenterology and Motility
|August 14, 2019
PubMed

Insights

Pediatric gastroparesis (GP) differs from adult GP in causes, symptoms, and treatment response. More research is needed to understand childhood GP and develop targeted therapies for better outcomes.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Motility Disorders

Background:

  • Limited understanding of childhood gastroparesis (GP) incidence, prevalence, and natural history.
  • Lack of normative data for pediatric gastric emptying scintigraphy.
  • Absence of validated GP-specific outcome measures for children.

Purpose of the Study:

  • Review existing literature on pediatric GP.
  • Identify similarities and differences between pediatric and adult GP.
  • Highlight areas for future research in childhood GP.

Main Methods:

  • Comprehensive literature search of MEDLINE and Google Scholar (inception to April 2019).
  • Keywords included gastroparesis, pediatric gastroparesis, outcomes, and specific medications/treatments.
  • Analysis of available pediatric data, often retrospective.

Main Results:

  • Pediatric GP data suggest significant differences from adult GP.
  • Differences observed in etiology, comorbidities (e.g., psychiatric disorders), symptom presentation, and diagnostic approaches.
  • Variations noted in treatment response and overall clinical outcomes between pediatric and adult populations.

Conclusions:

  • Pediatric gastroparesis presents uniquely compared to adults.
  • Further research is crucial to elucidate pediatric GP mechanisms.
  • Development of pediatric-focused therapies is warranted for improved management.
Abstract

Keywords:
gastric emptyinggastroparesismotilitypediatric gastroenterology

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