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Updated: Jan 21, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
Associated ileocaecal location is a marker for greater severity of low rectal endometriosis
L Marcellin1,2, M Leconte2,3, S Gaujoux2,3
1Département de Gynécologie Obsétrique II et Médecine de la Reproduction (Professeur Chapron), Assistance Publique-Hôpitaux de Paris (AP-HP), Centre Hospitalier Universitaire (CHU) Cochin, Hôpital Universitaire Paris Centre (HUPC), Paris, France.
Objective:
To determine whether ileocaecal endometriosis (ICE) is a marker for low rectal endometriosis (LRE) severity.
Design:
Retrospective cohort study.
Setting:
France.
Population And Sample:
Analysis of 375 colorectal resections performed in women undergoing complete surgery for LRE from January 1995 to December 2015 in a university centre for endometriosis.
Methods:
Univariate and multivariate analysis of anatomical, postoperative clinical, and long-term outcomes according to presence of ICE.
Main Outcomes And Measures:
Mean number and type of deep infiltrating endometriosis (DIE) lesions, the existence of an associated endometrioma, and mean total American Society for Reproductive Medicine (ASRM) score.
Results:
The prevalence of ICE was 25.6%. Primary end-point data showed that women with ICE had a significantly higher adjusted number of DIE lesions (OR = 1.43, 95% CI 1.02-3.03; P = 0.048), higher prevalence of endometriomas (OR = 1.91, 95% CI 1.04-3.51; P = 0.044), more associated DIE sigmoid lesions (OR = 2.12, 95% CI 1.07-3.91; P = 0.025), and a higher mean total ASRM score (OR = 2.07, 95% CI 1.12-4.14; P = 0.025). Women with ICE resected during the surgical procedure for LRE did not have more adverse postoperative clinical outcomes than ICE-negative patients.
Conclusion:
Ileocaecal endometriosis was significantly associated with greater LRE severity. In a complete surgical resection strategy, combining resection of ICE and LRE did not appear to increase postoperative rates of complications, morbidity or recurrence, nor did it seem to impair long-term clinical outcomes.
Tweetable Abstract:
In women with low rectal endometriosis, 25% have an associated ileocaecal location that is a marker for severity.
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