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Updated: Jan 21, 2026
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Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice
Published on: September 26, 2019
9.8K
Can emphysema influence size discrepancy between radiologic and pathologic size measurement in subsolid lung
Jae-Kwang Lim1, Kyung Min Shin1, Sang Yub Lee1
1Department of Radiology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Thoracic Cancer
|August 14, 2019
Summary
Emphysema presence affects subsolid lung adenocarcinoma measurements on thin-section computed tomography (TSCT), leading to underestimation of solid tumor size and impacting T staging accuracy compared to pathology.
Area of Science:
- Radiology
- Oncology
- Pulmonology
Background:
- Subsolid lung adenocarcinomas (SSNs) require accurate size measurement for staging.
- Emphysema can potentially alter the accuracy of computed tomography (CT) measurements.
Purpose of the Study:
- To investigate how the presence of emphysema influences the measured diameter of subsolid lung adenocarcinomas using thin-section computed tomography (TSCT) compared to pathological measurements.
Main Methods:
- Analysis of 268 surgically resected SSNs from 252 patients.
- Two observers measured whole tumor (WTsize) and solid tumor (STsize) diameters on TSCT.
- Comparison of CT measurements with pathological size (Psize) and invasive size (PIsize).
Main Results:
- Strong interobserver agreement for WTsize and STsize measurements.
- Radiologic WTsize was significantly larger than Psize; STsize was smaller than PIsize.
- Emphysema group showed better correlation of WTsize with Psize, while the normal lung group showed better correlation of STsize with PIsize.
Conclusions:
- Solid tumor size (STsize) on TSCT is underestimated in patients with emphysema.
- This underestimation leads to increased discordance in T staging between TSCT and pathology for SSNs in patients with emphysema.
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