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Updated: Jan 21, 2026

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
Published on: March 25, 2015
[Stiff-person syndrome: a clinical observation]
N V Isaeva1, S V Prokopenko1, M V Rodikov2
1Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia; Regional Clinical Hospital, Krasnoyarsk, Russia.
Abstract:
Stiff-person syndrome (SPS) is a rare chronic neurological disease characterized by progressing muscle rigidity and painful muscle spasms. The signs of SPS are pain and stiffness in spinal, abdominal and cervical muscles, increased muscle tonus in extensor muscles of extremities, constant stiffness of paravertebral and abdominal muscles and muscle spasms. A clinical case of a SPS patient T., aged 23 years, is presented. The peculiarity of this case is additional left-sided peripheral upper extremity monoparesis, which is most likely associated with the development of left-sided compression-ischemic brachial plexopathy resulted from profound muscular tonic syndrome in the neck and shoulder girdles.
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