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Updated: Jan 21, 2026
07:23
Electroporation of Craniofacial Mesenchyme
Published on: November 28, 2011
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Case series: Amniotic band sequence with craniofacial abnormalities.
Shelby Lies1, Terri Beckwith1, Janith Mills1
1Department of Hand and Upper Extremity, Texas Scottish Rite Hospital for Children, Dallas, Texas.
Birth Defects Research
|August 14, 2019
Summary
Amniotic band syndrome (ABS) can cause rare craniofacial abnormalities, including cleft lip and palate, alongside vision and neurological issues. The complex features suggest a multifactorial cause beyond simple amniotic disruption.
Area of Science:
- Medical Genetics
- Developmental Biology
- Pediatric Surgery
Background:
- Amniotic band syndrome (ABS) is a rare congenital disorder.
- Characterized by fibrous bands constricting fetal parts.
- Often associated with limb defects, but craniofacial involvement is less common.
Observation:
- A retrospective case series of seven patients with ABS and craniofacial anomalies.
- Detailed review of medical records, focusing on craniofacial, visual, and neurological features.
- Collected data included demographics, birth history, physical exams, and diagnostic tests.
Findings:
- All seven patients exhibited cleft lip, with six also having cleft palate.
- Other craniofacial anomalies included facial clefts, tear duct issues, cranial deformities, hypertelorism, coloboma, and optic nerve dysplasia.
- Visual and neurological symptoms were frequently observed.
Implications:
- Craniofacial anomalies in ABS are rare but significant.
- The observed dysmorphology is complex and likely multifactorial, not solely due to amniotic membrane disruption.
- Highlights the need for comprehensive evaluation of patients with ABS for associated anomalies.
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