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Updated: Jan 21, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
Published on: June 6, 2016
Behavioural inhibition and valuation of gain/loss are neurally distinct from approach/withdrawal
Neil McNaughton1, Philip J Corr2
1Department of Psychology, University of Otago, Dunedin 9054, New Zealandneil.mcnaughton@otago.ac.nzhttp://www.otago.ac.nz/psychology/staff/neilmcnaughton.html.
Abstract:
Gain or omission/termination of loss produces approach; while loss or omission/termination of gain produces withdrawal. Control of approach/withdrawal motivation is distinct from valuation of gain/loss and does not entail learning - making "reward" and "punishment" ambiguous. Approach-withdrawal goal conflict engages a neurally distinct Behavioural Inhibition System, which controls "anxiety" (conflict/passive avoidance) but not "fear" (withdrawal/active avoidance).
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