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Whole-brain functional network disruption in chronic pain with disk herniation
Shishi Huang1,2, Kenta Wakaizumi3,4, Binbin Wu1,5
1China-USA Neuroimaging Research Institute, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Pain
|August 14, 2019
Summary
Brain network disruptions are evident in chronic back pain patients with lumbar disk herniation (LDH). These changes in functional connectivity may differ based on pain type and cultural factors.
Area of Science:
- Neuroscience
- Medical Imaging
- Pain Research
Background:
- Musculoskeletal chronic pain conditions exhibit global disruptions in brain functional networks.
- Lumbar disk herniation (LDH) is a common cause of back pain and can lead to chronic pain.
- Brain functional network properties in LDH-chronic pain patients are not well understood.
Purpose of the Study:
- To investigate brain functional network properties in patients with LDH-chronic pain using resting-state functional magnetic resonance imaging (rs-fMRI).
- To explore potential cultural influences on brain functional reorganization in chronic pain patients from China.
Main Methods:
- rs-fMRI data were analyzed to assess functional connectivity networks in 146 LDH-chronic pain patients and 165 healthy controls (HCs).
- Data were divided into discovery and validation subgroups and contrasted with an external dataset (NITRC 1000).
- Graph disruption indices (degree, clustering coefficient, efficiency) were calculated to represent network hubness, segregation, and integration.
Main Results:
- Graph disruption indices were significantly decreased in LDH-chronic pain patients compared to HCs across discovery and validation groups.
- Global mean clustering coefficient and betweenness centrality showed decreases in the discovery group and a trend in the validation group.
- The association between pain and graph disruption indices was observed primarily in males with higher education.
Conclusions:
- Chronic back pain associated with LDH is characterized by global disruptions in brain functional networks.
- Observed differences in network properties may be influenced by pain type or cultural factors, warranting further investigation.
- Findings contribute to understanding the neurobiological underpinnings of chronic pain and potential cultural variations.
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