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[Antifungigram of dermatophytes]
R Steiman1, F Seigle-Murandi, L Sage
1Laboratoire de Botanique, Cryptogamie, Biologie Cellulaire et Génétique UFR de Pharmacie, Meylan, (France).
Annales De L'Institut Pasteur. Microbiology
|July 1, 1988
Summary
This study evaluated antifungal agents against Microsporum gypseum, finding imidazole compounds most effective. Optimal sensitivity was observed using spores on a complex Casitone medium.
Area of Science:
- Mycology
- Antimicrobial Susceptibility Testing
Context:
- Dermatophyte infections caused by fungi like Microsporum and Trichophyton species are common.
- Evaluating the efficacy of antifungal agents is crucial for treating these infections.
- Understanding the influence of culture conditions on fungal susceptibility is important for accurate testing.
Purpose:
- To determine the sensitivity of Microsporum gypseum to five antifungal agents.
- To investigate the impact of culture medium composition and the physiological state of the microorganism on antifungal efficacy.
- To compare the effectiveness of imidazole compounds against amphotericin B and nystatin.
Summary:
- The disk diffusion method was employed to assess the antifungal sensitivity of Microsporum gypseum.
- Comparative analysis of antifungal disk settings revealed differential effects on fungal spores and mycelia.
- Casitone, a complex medium, yielded the best results when using fungal spores as the inoculum.
- Sensitivity testing across Microsporum canis, M. gypseum, and Trichophyton interdigital highlighted the superior efficacy of imidazole compounds over amphotericin B and nystatin.
Impact:
- Provides data on the comparative efficacy of different antifungal agents against key dermatophytes.
- Highlights the importance of optimizing culture media and inoculum type for reliable antifungal susceptibility testing.
- Informs clinical treatment strategies for dermatophytosis by identifying potent antifungal compounds.