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Renin-angiotensin system in osteoarthritis: A new potential therapy
Yuangang Wu1, Xiaoxi Lu2, Mingyang Li1
1Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China.
Abstract:
Osteoarthritis (OA) is one of the most common chronic joint diseases. However, the mechanism remains unclear. The traditional renin-angiotensin system (RAS) is an important system for regulating homeostasis and controlling balance. In recent years, RAS-related components have played an important role in the occurrence of OA. The purpose of this review is to summarize the research results of RAS-related components that are associated with OA. This study systematically searched e-medical databases such as PubMed, Embase, Medline, and Web of Science. The search targets included English publications describing the effects of RAS-related components in OA, including the role of renin, angiotensin-converting enzyme (ACE), Angiotensin II (Ang II), and angiotensin receptor (ATR). Additionally, this study summarizes the potential pathways for RAS-related components to intervene in OA. This study found that RAS-related components including renin, ACE, Ang II, AT1R and AT2R are involved in inflammation and chondrocyte hypertrophy in OA. RAS is involved in signaling pathways including the NF-κB, JNK, VEGFR/Tie-2, and the Axna2/Axna2R axis ones, which may be potential targets for the treatment of OA. Although there are few studies on RAS in the field of OA, the pathogenic effect of RAS-related components is still an important topic in OA treatment, and great progress may be made in this aspect in future studies.
Insights
The renin-angiotensin system (RAS) components, including renin, ACE, Ang II, AT1R, and AT2R, contribute to osteoarthritis (OA) by promoting inflammation and chondrocyte hypertrophy. Targeting these RAS elements offers potential new treatments for OA.
Area of Science:
- Biomedical Science
- Rheumatology
- Molecular Biology
Background:
- Osteoarthritis (OA) is a prevalent chronic joint disease with incompletely understood mechanisms.
- The renin-angiotensin system (RAS) is crucial for homeostasis and increasingly implicated in OA pathogenesis.
Purpose of the Study:
- To review and synthesize current research on the association between RAS components and osteoarthritis.
- To identify potential therapeutic targets within the RAS for OA intervention.
Main Methods:
- Systematic literature search of major e-medical databases (PubMed, Embase, Medline, Web of Science).
- Inclusion of English publications detailing the roles of renin, ACE, Ang II, and ATR in OA.
- Summary of identified signaling pathways involved in RAS-mediated OA.
Main Results:
- RAS components (renin, ACE, Ang II, AT1R, AT2R) are implicated in OA-related inflammation and chondrocyte hypertrophy.
- RAS influences OA through signaling pathways such as NF-κB, JNK, VEGFR/Tie-2, and the Axna2/Axna2R axis.
- These pathways represent potential targets for novel OA treatments.
Conclusions:
- RAS components play a significant role in the development and progression of osteoarthritis.
- Targeting the RAS offers a promising avenue for future OA therapeutic strategies.
- Further research into RAS modulation could lead to significant advancements in OA treatment.
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