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Updated: Jan 21, 2026
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Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
Published on: September 21, 2018
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Stress Determined through Heart Rate Variability Predicts Immune Function.
Hong Luo1, Jing Wei1, Yousef Yasin2
1The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Neuroimmunomodulation
|August 14, 2019
Summary
Heart rate variability (HRV) analysis from ECG can noninvasively assess stress and predict immune function. This inexpensive method may aid in managing stress-related health risks by indexing immune cell percentages.
Area of Science:
- Cardiology
- Immunology
- Public Health
Background:
- Chronic stress can impair immune function, necessitating effective stress assessment in public health.
- Electrocardiography (ECG) and heart rate variability (HRV) are used for cardiovascular assessment and stress inference.
- The link between HRV-based stress assessment and immune function requires further investigation.
Purpose of the Study:
- To compare stress levels measured by HRV (pNN50) from ECG with immune function indicators (neutrophil, monocyte, lymphocyte percentages) from blood samples.
Main Methods:
- 184 healthy adults underwent a 2-minute ECG recording and blood draw.
- Stress was quantified using pNN50 from ECG data.
- Immune cell percentages were determined from blood samples.
Main Results:
- Stress (pNN50) showed a positive correlation with neutrophil percentages (r = 0.21).
- Stress exhibited negative correlations with monocyte (r = -0.16) and lymphocyte percentages (r = -0.18).
Conclusions:
- HRV analysis offers a viable, noninvasive, and inexpensive method for indexing stress.
- HRV analysis may predict immune function, aiding in the management of stress-related health risks.
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