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Stress Determined through Heart Rate Variability Predicts Immune Function.

Hong Luo1, Jing Wei1, Yousef Yasin2

  • 1The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Neuroimmunomodulation
|August 14, 2019
PubMed
Summary

Heart rate variability (HRV) analysis from ECG can noninvasively assess stress and predict immune function. This inexpensive method may aid in managing stress-related health risks by indexing immune cell percentages.

Keywords:
ElectrocardiographyHeart rate variabilityImmune functionStresspNN50

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Area of Science:

  • Cardiology
  • Immunology
  • Public Health

Background:

  • Chronic stress can impair immune function, necessitating effective stress assessment in public health.
  • Electrocardiography (ECG) and heart rate variability (HRV) are used for cardiovascular assessment and stress inference.
  • The link between HRV-based stress assessment and immune function requires further investigation.

Purpose of the Study:

  • To compare stress levels measured by HRV (pNN50) from ECG with immune function indicators (neutrophil, monocyte, lymphocyte percentages) from blood samples.

Main Methods:

  • 184 healthy adults underwent a 2-minute ECG recording and blood draw.
  • Stress was quantified using pNN50 from ECG data.
  • Immune cell percentages were determined from blood samples.

Main Results:

  • Stress (pNN50) showed a positive correlation with neutrophil percentages (r = 0.21).
  • Stress exhibited negative correlations with monocyte (r = -0.16) and lymphocyte percentages (r = -0.18).

Conclusions:

  • HRV analysis offers a viable, noninvasive, and inexpensive method for indexing stress.
  • HRV analysis may predict immune function, aiding in the management of stress-related health risks.