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Cerebral arterial stiffness for predicting functional outcome in acute ischemic stroke
Xian Fu1, Changbiao Chu1, Xianliang Li2
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Summary
Cerebral arterial stiffness, measured by carotid-cerebral pulse wave velocity (ccPWV), independently predicts poor functional outcomes in acute ischemic stroke (AIS) patients. Higher ccPWV values indicate increased stroke risk and poorer recovery.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Biomedical Engineering
Background:
- Acute ischemic stroke (AIS) poses a significant challenge to functional recovery.
- Cerebral arterial stiffness is an emerging factor influencing stroke outcomes.
- Predictive markers for long-term functional prognosis in AIS are crucial.
Purpose of the Study:
- To evaluate the association between cerebral arterial stiffness, quantified by carotid-cerebral pulse wave velocity (ccPWV), and functional outcomes in AIS patients.
- To identify ccPWV as a potential independent predictor of poor functional recovery after AIS.
Main Methods:
- Prospective study of 336 first-ever AIS patients.
- Assessment included multimodal brain MRI, ccPWV, echocardiography, and carotid ultrasonography.
- Functional outcome was assessed using the modified Rankin Scale at 3 months post-stroke.
Main Results:
- A poor functional outcome (modified Rankin Scale >2) was observed in 32.74% of patients.
- ccPWV ≥ 6.66 m/s was an independent predictor of poor functional outcome (adjusted OR, 6.27).
- ccPWV demonstrated high predictive accuracy (AUC 85.27%) for 3-month functional outcome.
Conclusions:
- Cerebral arterial stiffness, measured by ccPWV on admission, is a valuable independent prognostic factor for long-term functional outcome in AIS.
- ccPWV measurement can significantly improve the prediction of functional outcomes in AIS patients.
- This finding supports the integration of ccPWV assessment in stroke management protocols.
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